Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced eosinophilia-associated cytokine production by nasal polyps
نویسندگان
چکیده
منابع مشابه
Induction of nasal polyps using house dust mite and Staphylococcal enterotoxin B in C57BL/6 mice.
BACKGROUND The murine polyp model was developed previously using ovalbumin and Staphylococcus aureus enterotoxin B (SEB). Here, we established a model mimicking key aspects of chronic eosinophilic rhinosinusitis with nasal polyps using the house dust mite (HDM), a clinically relevant aeroallergen, co-administered with SEB. We assessed the inflammatory response and formation of nasal polypoid le...
متن کاملDifferential inhibitory effects of interleukin-10, interleukin-4, and dexamethasone on staphylococcal enterotoxin-induced cytokine production and T cell activation.
The cytokine profile of human peripheral blood mononuclear cells (PBMC) stimulated by staphylococcal enterotoxin (SE) A and B was examined. Production of tumor necrosis factor (TNF alpha), interleukin (IL)-1, IL-6, IL-2, and gamma interferon (IFN-gamma) was observed. In contrast, Th2 cytokines IL-4 and IL-10 were absent from SEA- or SEB-stimulated PBMC. Moreover, adding IL-10 to SE-stimulated P...
متن کاملDistinct characteristics of nasal polyps with and without eosinophilia.
INTRODUCTION Eosinophilic and noneosinophilic Nasal polyps (NPs) are different subtypes of NPs and require different treatment methods. OBJECTIVE To compare the histologic characteristics, mRNA and protein expression between Nasal Polyps with and without eosinophilia. METHODS NPs tissues were obtained from eighty-six NPs patients during surgery. Eosinophilic and noneosinophilic NPs were dis...
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15 صفحه اولProduction of staphylococcal enterotoxin A on cellophage-over-agar.
Up to approximately 50 mug of staphylococcal enterotoxin A per plate was produced by cellophane-over-agar cultures. Enterotoxin was determined by a latex agglutination technique.
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ژورنال
عنوان ژورنال: Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)
سال: 2016
ISSN: 0910-9153,1883-7077
DOI: 10.7248/jjrhi.55.121